Francis II may refer to:

• Francis II, Duke of Brittany (1433–1488)
• Francesco II Gonzaga, Marquess of Mantua (1466–1519), ruler of the Italian city of Mantua
• Francis II of France (1544–1560), king of France
• Francis II, Duke of Lorraine (1572–1632), son of Charles III, Duke of Lorraine, and Claude of Valois
• Francesco II d'Este, Duke of Modena (1660–1694)
• Francis II Rákóczi (1676–1735), Prince of Transylvania
• Francis II, Holy Roman Emperor (1768–1835), last Holy Roman Emperor
• Francis II of the Two Sicilies (1836–1894), last king of the Two Sicilies
• Franz, Duke of Bavaria (born 1933), called "Francis II" by supporters of the Jacobite claim to the thrones of England, Scotland, Ireland, and France
• Francis II, Duke of Saxe-Lauenburg (1547–1619), third son of Francis I of Saxe-Lauenburg and Sybille of Saxe-Freiberg

• Francesco II (disambiguation)
• Franz Joseph II, Prince of Liechtenstein

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