Feline_sarcoma_oncogene

Tyrosine-protein kinase Fes/Fps

Tyrosine-protein kinase Fes/Fps

Human protein and coding gene

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.[5][6] FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.[7]

Quick Facts FES, Available structures ...

Function

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.[8]

Interactions

Feline sarcoma oncogene has been shown to interact with BCAR1[9] and BCR gene.[10][11]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000182511 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000053158 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Bowden DW, Akots G, Rothschild CB (Aug 1991). "An insertion deletion polymorphism associated with C-FES". Nucleic Acids Research. 19 (15): 4311. doi:10.1093/nar/19.15.4311. PMC 328602. PMID 1870997.
  6. [6]
    "FES - Tyrosine-protein kinase Fes/Fps - Homo sapiens (Human) - FES gene & protein". www.uniprot.org. Retrieved 16 May 2022.
  7. [7]
    Craig AW (2012). "FES/FER kinase signaling in hematopoietic cells and leukemias". Frontiers in Bioscience. 17 (3): 861–75. doi:10.2741/3961. PMID 22201778.
  8. [8]
    "Entrez Gene: FES feline sarcoma oncogene".
  9. [9]
    Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA (Jan 1997). "The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling". The Journal of Biological Chemistry. 272 (4): 2104–9. doi:10.1074/jbc.272.4.2104. PMID 8999909.
  10. [10]
    Lionberger JM, Smithgall TE (Feb 2000). "The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl". Cancer Research. 60 (4): 1097–103. PMID 10706130.
  11. [11]
    Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE (Feb 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and Cellular Biology. 15 (2): 835–42. doi:10.1128/MCB.15.2.835. PMC 231961. PMID 7529874.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: P07332 (Tyrosine-protein kinase Fes/Fps) at the PDBe-KB.


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This article uses material from the Wikipedia article Feline_sarcoma_oncogene, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.