Estradiol_17a-dehydrogenase
In enzymology, estradiol 17alpha-dehydrogenase (EC 1.1.1.148) is a crucial enzyme that catalyzes the chemical reaction: Estradiol-17alpha + NAD(P)+ ↔ Estrone + NAD(P)H + H+ The enzyme's substrates include estradiol-17alpha, NAD+, and NADP+, while its products consist of estrone, NADH, NADPH, and H+. Estradiol 17alpha-dehydrogenase belongs to the oxidoreductase family, specifically those acting on the CH-OH group of donors with NAD+ or NADP+ as acceptors. The systematic name for this enzyme class is 17alpha-hydroxysteroid:NAD(P)+ 17-oxidoreductase. Commonly used names include 17alpha-estradiol dehydrogenase, 17alpha-hydroxy steroid dehydrogenase, 17alpha-hydroxy steroid oxidoreductase, 17alpha-hydroxysteroid oxidoreductase, and estradiol 17alpha-oxidoreductase. This enzyme plays a crucial role in both androgen and estrogen metabolism.