Murong Chui married Duan Yuanfei in or slightly earlier than 388. His younger brother Murong De married her sister Duan Jifei around the same time. He created her empress in 388 and favored her greatly. They had two sons, Murong Lang (慕容朗) the Prince of Bohai and Murong Jian (慕容鑒) the Prince of Boling.
Empress Duan was described as being intelligent and a good judge of character. As she saw that Murong Chui's crown prince Murong Bao lacked governing talents, she tried to persuade him to make one of his more capable sons, Murong Nong the Prince of Liaoxi or Murong Long the Prince of Gaoyang, crown prince, but Murong Chui, believing in the flattery that Murong Bao's associates had given him, disbelieved Empress Duan and kept Murong Bao as crown prince. She had also advised him to put his treacherous son Murong Lin the Prince of Zhao to death. As a result, Murong Bao and Murong Lin greatly resented her.
After Murong Chui died in 396, Murong Bao sent Murong Lin to threaten her and force her to commit suicide—stating that if she did not, he would do harm to her clan. In anger, she stated that Murong Bao would soon cause the empire's destruction, and then committed suicide. Initially, Murong Bao refused to give her an empress' burial honors, but after his official Sui Sui (眭邃) publicly articulated reasons why she should be honored, Murong Bao relented and buried her with imperial honors.