Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.^[5][6][7]

Quick Facts AGO2, Available structures ...

AGO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LUC, 3LUD, 3LUG, 3LUH, 3LUJ, 3LUK, 3QX8, 3QX9, 4F3T, 4OLA, 4OLB, 4W5N, 4W5O, 4W5Q, 4W5R, 4W5T, 4Z4C, 4Z4D, 4Z4E, 4Z4F, 4Z4G, 4Z4H, 4Z4I, 5JS1, 5JS2
Identifiers
Aliases	AGO2, EIF2C2, Q10, argonaute 2, RISC catalytic component, PPD, CASC7, LINC00980, argonaute RISC catalytic component 2, LESKRES
External IDs	OMIM: 606229; MGI: 2446632; HomoloGene: 81825; GeneCards: AGO2; OMA:AGO2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 140,520,156 bp[1] End 140,635,633 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 72,967,693 bp[2] End 73,056,784 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon cartilage tissue tail of epididymis superficial temporal artery trabecular bone corpus epididymis mucosa of paranasal sinus lower lobe of lung tendon Achilles tendon Top expressed in ascending aorta hand aortic valve supraoptic nucleus ventromedial nucleus suprachiasmatic nucleus foot paraventricular nucleus of hypothalamus arcuate nucleus blood More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein C-terminus binding metal ion binding nuclease activity endoribonuclease activity, cleaving miRNA-paired mRNA hydrolase activity translation initiation factor activity endonuclease activity endoribonuclease activity, cleaving siRNA-paired mRNA single-stranded RNA binding double-stranded RNA binding RNA polymerase II complex binding nucleic acid binding mRNA binding miRNA binding endoribonuclease activity RNA 7-methylguanosine cap binding siRNA binding mRNA cap binding RNA binding endoribonuclease activity, producing 5'-phosphomonoesters Cellular component cytoplasm polysome membrane P-body dendrite RISC-loading complex RISC complex cytosol nucleus nucleoplasm mRNA cap binding complex cell junction extracellular exosome ribonucleoprotein complex Biological process mRNA destabilization-mediated gene silencing by miRNA RNA secondary structure unwinding transcription, DNA-templated regulation of translation RNA interference protein biosynthesis positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay positive regulation of gene expression production of miRNAs involved in gene silencing by miRNA mRNA destabilization-mediated gene silencing by siRNA positive regulation of nuclear-transcribed mRNA poly(A) tail shortening pre-miRNA processing regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II post-embryonic development RNA phosphodiester bond hydrolysis, endonucleolytic translational initiation Wnt signaling pathway, calcium modulating pathway miRNA-mediated gene silencing by inhibition of translation negative regulation of translational initiation miRNA metabolic process production of siRNA involved in RNA interference gene silencing regulation of gene silencing by miRNA negative regulation of gene expression positive regulation of angiogenesis positive regulation of trophoblast cell migration negative regulation of amyloid precursor protein biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27161 239528 Ensembl ENSG00000123908 ENSMUSG00000036698 UniProt Q9UKV8 Q8CJG0 RefSeq (mRNA) NM_001164623 NM_012154 NM_153178 RefSeq (protein) NP_001158095 NP_036286 NP_694818 Location (UCSC) Chr 8: 140.52 – 140.64 Mb Chr 15: 72.97 – 73.06 Mb PubMed search [3] [4]
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This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.^[7]

EIF2C2 has been shown to interact with

• DDX20,^[8][9]
• DICER1,^[9][10]
• FMRP, FXR1P, FXR2P,^[11] and
• TNRC6B.^[12]