Josquin des Prez (or Desprez) (c. 1450 – 1521) was a composer of High Renaissance music

Desprez or des Prez may also refer to:

• Florian Desprez, aka Julian Florian Félix Desprez (1807–1895), French bishop and cardinal
• Frank Desprez (1853–1916), English playwright, essayist, and poet
• Louis Desprez (1799–1870), French sculptor
• Louis Jean Desprez (c. 1743–1804), French painter and architect
• Jean Desprez (aka Laurette Larocque, 1906–1965), French-Canadian writer and journalist
• Sainte des Prez(13th century), a trouvère poet-composer
• Desprez (actor) (1759–1829), French actor

• Desprez Lake, a lake in Quebec, Canada
• Despréz (crater), a crater on Mercury

• Despres, also Després, Desprès, des Prés, Des Pres; French surname
• Deprez

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