DHH_(hedgehog)
Desert hedgehog (protein)
Protein-coding gene in the species Homo sapiens
Desert hedgehog, also Desert hedgehog homolog or Dhh, is a protein encoded by the DHH gene, and is a member of the hedgehog signaling pathway. The human homolog (DHH) is on chromosome band 12q13.1.[5][6] The protein encoded by this gene is involved in cell signaling. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the desert hedgehog is honored by this one. The gene is not specific to desert hedgehogs.
DHH | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | DHH, GDXYM, HHG-3, SRXY7, C78960, desert hedgehog, desert hedgehog signaling molecule, GDMN | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605423; MGI: 94891; HomoloGene: 22431; GeneCards: DHH; OMA:DHH - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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desert hedgehog | |||||||
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Identifiers | |||||||
Symbol | DHH | ||||||
Alt. symbols | HHG-3, MGC35145 | ||||||
NCBI gene | 50846 | ||||||
HGNC | 2865 | ||||||
OMIM | 605423 | ||||||
RefSeq | NM_021044 | ||||||
UniProt | O43323 | ||||||
Other data | |||||||
Locus | Chr. 12 q13.1 | ||||||
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This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism.
Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.[7]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- DHH protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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