In enzymology, a D-lactate dehydrogenase (cytochrome c-553) (EC 1.1.2.5) is an enzyme that catalyzes the chemical reaction

(R)-lactate + 2 ferricytochrome c-553 ${\displaystyle \rightleftharpoons }$ pyruvate + 2 ferrocytochrome c-553

This January 2023 relies largely or entirely on a single source. (January 2023)

Thus, the two substrates of this enzyme are (R)-lactate and ferricytochrome c-553, whereas its two products are pyruvate and ferrocytochrome c-553.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with a cytochrome as acceptor. The systematic name of this enzyme class is (R)-lactate:ferricytochrome-c-553 2-oxidoreductase. This enzyme participates in pyruvate metabolism.