Cysteamine_dioxygenase

Cysteamine dioxygenase

Cysteamine dioxygenase

Class of enzymes

In enzymology, a cysteamine dioxygenase (EC 1.13.11.19) is an enzyme that catalyzes the chemical reaction

2-aminoethanethiol + O2 hypotaurine
Quick Facts Identifiers, EC no. ...

Thus, the two substrates of this enzyme are 2-aminoethanethiol and O2, whereas its product is hypotaurine.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2-aminoethanethiol:oxygen oxidoreductase. Other names in common use include persulfurase, cysteamine oxygenase, and cysteamine:oxygen oxidoreductase. This enzyme participates in taurine and hypotaurine metabolism. It employs one cofactor, iron.

References

    • Cavallini D, De Marco C, Scandurra R, Dupre S, Graziani MT (1966). "The enzymatic oxidation of cysteamine to hypotaurine. Purification and properties of the enzyme". J. Biol. Chem. 241 (13): 3189–96. PMID 5912113.
    • Wood JL, Cavallini D (1967). "Enzymic oxidation of cysteamine to hypotaurine in the absence of a cofactor". Arch. Biochem. Biophys. 119 (1): 368–72. doi:10.1016/0003-9861(67)90467-5. PMID 6052430.
    • Cavallini D, Federici G, Ricci G, Dupre S, Antonucci A (1975). "The specificity of cysteamine oxygenase". FEBS Lett. 56 (2): 348–51. doi:10.1016/0014-5793(75)81124-0. PMID 1157952.
    • Richerson RB, Ziegler DM (1987). "Sulfur and Sulfur Amino Acids. Cysteamine dioxygenase". Methods Enzymol. Methods in Enzymology. 143: 410–5. doi:10.1016/0076-6879(87)43071-1. ISBN 978-0-12-182043-5. PMID 3657558.


    This EC 1.13 enzyme-related article is a stub. You can help Wikipedia by expanding it.
    Share this article:

    This article uses material from the Wikipedia article Cysteamine_dioxygenase, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.