Early Origins

The Cardinals and Rams are some of the oldest surviving members of the National Football League; the Chicago Cardinals originally formed in 1898 and the Cleveland Rams were an expansion team that joined in 1936. Early on, both teams were pitted against each other in what was then the NFL Western division. Both clubs saw personnel struggles during World War II as neither team posted a winning season until 1944. The Rams and Cardinals would combine for 2 NFL Championships in 1945 and 1947 respectively, the latter being the most recent championship won by the Cardinals.

1950s & 60s

After 1950, matchups between the two teams were not regular again until the division realignment in 2002. Rams then-owner Dan Reeves previously relocated the team to Los Angeles following the 1946 season, and the Cardinals would shift to the American Conference from 1950-52, before encountering financial difficulties throughout the 1950s, ultimately leading them to relocate to St. Louis in 1960 as part of a bid from the league to prevent an AFL team from taking the St. Louis market. The Cardinals would begin to struggle mightily through the decades following their lone championship in 1947 and would not make a playoff appearance until 1974.^[7] Due to the shift in divisions and the reorganization following the merger with the AFL, the Rams and Cardinals only met 3 times between 1960 and 1968.

1970s

The two franchises took very different paths during the 1970s. The Cardinals made back to back Divisional Round appearances in 1974 and 1975, while the Rams would made continuous postseason appearances from 1973 to 1979. These playoff appearances included a 1975 Divisional Round matchup against the Cardinals, the first postseason meeting between the two clubs. The Rams defense scored 2 touchdowns in the first half while running back Lawrence McCutcheon ran for an NFL playoff record 202 yards on 37 carries. Los Angeles started the game off with a 79-yard scoring drive. The Cardinals were extremely outmatched against the Rams defense as quarterback Jim Hart threw a critical interception that was returned for a pick-6. Hart would finish the game with 3 interceptions as the Rams were well beyond out of reach.

This would go onto be the Cardinals' last playoff appearance until 1982, and their last in a non-strike season until 1998, a decade after the franchise moved to Arizona. The two teams would meet again in the 1979 season, but the Rams dominated the game, shutting out the Cardinals 21–0.

The Rams were an aspiring playoff contender throughout the 1970s but would go onto lose in 4 straight Conference Championship games and lose an appearance in Super Bowl XIV.

1980s

The Cardinals did not fare terribly well during the 1980s as the Rams would go onto boast a 6-game win streak in the series from 1979 to 1987. The Cardinals also would make their only playoff appearance of the decade during the 1982 postseason, but would fall to the Green Bay Packers. The Rams, meanwhile, were significantly competitive through the 1980s despite unstable ownership and a fight for the Los Angeles market with the Raiders relocating to LA in 1982. The Rams made 7 postseason appearances in the 1980s, but went on to lose twice in the conference championship to the 1985 Bears and the 1989 49ers. The Cardinals did not post a winning record from 1983 to 1998 and the club grew unsatisfied with the aging Busch Stadium, leading them to relocate to Phoenix, Arizona in 1988.

1990s

The Rams sought relocation in 1995 following a sharp decline in fan attendance in addition to the team's play. Ironically, owner Georgia Frontiere relocated the team to St. Louis to fill the void left by the Cardinals 7 years earlier. The Cardinals struggled through most of the decade but somehow slipped into the playoffs in 1998 with a lowly 9–7 record, and pulled off a win over the Dallas Cowboys. However, they fell against the notorious 1998 Minnesota Vikings and their high-powered offense. The Rams pulled off an improbable turnaround the very next season: they finished 1998 with a weak 4–12 record, but turned their fortunes around during the 1999 season boasting a 13–3 record and winning Super Bowl XXXIV as the iconic Greatest Show On Turf led by Quarterback Kurt Warner.

2000s

The new millennium fell in favor of the Rams briefly until they lost to the New England Patriots in Super Bowl XXXVI. The Cardinals were realigned back into the Rams’ division following the 2002 NFL season where they remain today. The Rams remained competitive briefly but never regained the levels of playoff success they experienced at the beginning of the decade as they would not make a playoff appearance from 2005 to 2016. The Cardinals also turned their own fortunes around later in the decade following the hiring of Ken Whisenhunt in 2007, and reached a high point for the franchise the following season by winning the NFC West and making their first super bowl appearance in franchise history, but fell to the Pittsburgh Steelers. Ironically, the Cardinals revived their playoff ambitions with former Rams quarterback, Super Bowl winner and NFL MVP Kurt Warner. The Cardinals would only manage another wild card berth but would not return to the postseason until 2014; meanwhile, the Rams bottomed out with a terrible 1–15 record in 2009.

2010s

Both teams entered the decade rebuilding. The Rams attempted to turn their team around with coach Jeff Fisher but would not prosper much beyond mediocre 7–9 records in 2013 and 2015 respectively. The Cardinals found themselves thriving again as general manager Steve Keim and Head Coach Bruce Arians brought them to a 10–6 record his first two seasons with the team, and led them to a playoff berth in 2014. The Cardinals also traded for quarterback Carson Palmer and see a renaissance of their offense as they went 13–3 and managed a trip to the 2015 NFC Championship, where they fell to the Carolina Panthers.^[8] Following the 2015 season, the Rams would relocate back to Los Angeles and take quarterback Jared Goff first overall in that year's draft. The Rams would post a poor 4–12 record their first season back in Los Angeles, but would go on to make the postseason with an 11-5 record following the hire of new head coach Sean McVay.^[9][10] During this time, the Rams would also manage to shut out the Cardinals during a game at London's Twickenham Stadium, the first shut-out the team experienced since 1992. The Cardinals sputtered to a 8–8 record, after which Carson Palmer and Bruce Arians retired. The team brought in Steve Wilks as their coach, though his tenure was very short and he was fired following the 2018 season. From 2017, the Rams swept the Cardinals in four consecutive seasons.^[11][12] 2018 also saw the Rams make a return to the Super Bowl for the first time since 2001, though they again fell to the New England Patriots. The Cardinals hired Texas Tech head coach Kliff Kingsbury to replace Keim at the start of the 2019 season, after which they drafted quarterback Kyler Murray first overall. The Rams also hit a slump that season following their Super Bowl appearance, and finished 9–7, missing the postseason.

2020s

The beginning of the decade saw strong play by of both teams yet again. The 2020 season saw the Cardinals breakout to a 6–3 record by week 9, one game ahead of the Rams who were 5–3 at their bye week. However they would only manage to win the remaining 4 of 7 games due to two upset losses to the 49ers and the then-winless New York Jets, the Rams lost control of the division followed by losing another critical rivalry matchup, (and ultimately the division lead) to the Seattle Seahawks. Arizona would fare even worse as they lost 5 of 7 games to finish the season tied for the lowest remaining wild card spot with the Chicago Bears. Both teams met during week 17 in Los Angeles for their regular season finale, notably the Rams had benched starting quarterback Jared Goff due to a thumb injury, and were forced to start backup quarterback John Wolford. Despite a 7–0 lead to finish the first quarter; the Rams would go onto humiliate the Cardinals, scoring 18 unanswered points in a crushing defeat. The loss ultimately gave the remaining wild card spot to the Bears; eliminating the Cardinals.

The 2021 season started with several drastic changes for the Rams as they traded Jared Goff and several draft picks to Detroit for quarterback Matthew Stafford.^[13] The Cardinals started the season 7–0, including a 37–20 win over the Rams in Los Angeles, ending their 8 game win streak over Arizona.^[14][15][16] The Rams entered the Monday Night matchup in Arizona with an 8–4 record as Arizona boasted a 10–2 record.^[17][18] However, the Rams won the return game in Glendale 30–23 in a hard-fought battle that saw Kyler Murray throw two interceptions, one critically turning the ball over in the fourth quarter, allowing the Rams to take the lead and eventually win.^[19] The Rams came back to win the division, while the Cardinals fell to a Wild Card spot, with the two facing off in the Wild Card round of the playoffs.^[20][21][22]

During the Wild Card game, the Cardinals were again quickly outgunned by the Rams as they were outscored 21–0 by halftime.^[23] During the third quarter, Rams running back Cam Akers unintentionally collided with Cardinals safety Budda Baker during a run. Akers was unaware Baker had suffered a concussion and was unable to get back up and playfully taunted him following the play.^[24] Following the arrival of medical personnel, Akers expressed his regret for the celebration and tweeted an apology for his taunt and expressed his support for Baker's recovery after the game.^[25][26] Despite Murray’s best efforts during the second half, the Rams would go on to crush the Cardinals 34–11 in the Cardinals' first postseason appearance since 2015 and eventually win Super Bowl LVI.

The 2022 season proved to be tumultuous for the Rams as they regressed massively from their Super Bowl winning roster; posting a meager 4–13 record in the process. They managed a victory against the Cardinals in Arizona, though collapsed the remainder of the season; losing the second matchup at home to Arizona, the second loss in Sean McVay's tenure to the Cardinals. The Cardinals managed a salvageable 4–6 record after beating the Rams, but went on to lose 7 straight matchups to also finish the season 4–13. Adding to Arizona's struggles to repeat a postseason appearance; longtime general manager Steve Keim resigned from his position on January 16, 2023; head coach Kliff Kingsbury was later fired on February 14.

The 2023 season saw the Rams attempting to salvage a depleted roster as they struggled to stay above .500 following a tightly lost contest against both the rival 49ers and Eagles. The Cardinals dealt with their own struggles after quarterback Kyler Murray suffered an ACL tear against the New England Patriots during the 2022 season; sidelining him indefinitely.^[27] The Cardinals entered the week 6 matchup with a lowly 1–4 record despite an upset victory over the Dallas Cowboys. Despite an early showing from both defenses, Arizona managed to inch ahead as neither team were able to score a single touchdown in the first half as the Cardinals led 9–6. The second half saw the Rams obliterate the Cardinals as their rookie running back Kyren Williams scythed through Arizona's defense for 158 yards. Backup quarterback Josh Dobbs was unable to overcome the Rams' defense in the second half as he later threw a critical interception at the 24 yard line. The Rams went onto shut out the Cardinals for the second half of the game as they scored 20 unanswered points to secure the victory.^[28]