CD247

T-cell surface glycoprotein CD3 zeta chain

T-cell surface glycoprotein CD3 zeta chain

Protein-coding gene in the species Homo sapiens

T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.[5]

Quick Facts CD247, Available structures ...

Some older literature mention a similar protein called "CD3 eta" in mice. It is now understood to be an isoform differing in the last exon.[6]

Genomics

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function

T-cell receptor zeta (ζ), together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]

Interactions

CD247 has been shown to interact with Janus kinase 3[8] and Protein unc-119 homolog.[9]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000198821 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000005763 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. Bibcode:1988PNAS...85.9709W. doi:10.1073/pnas.85.24.9709. PMC 282845. PMID 2974162.
  6. [6]
    Clayton LK, D'Adamio L, Howard FD, Sieh M, Hussey RE, Koyasu S, Reinherz EL (June 1991). "CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development". Proceedings of the National Academy of Sciences of the United States of America. 88 (12): 5202–6. doi:10.1073/pnas.88.12.5202. PMC 51840. PMID 1828894.
  7. [7]
    "Entrez Gene: CD247 CD247 molecule".
  8. [8]
    Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.
  9. [9]
    Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.

Further reading


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