Mangosuthu Buthelezi (1928–2023) was a South African politician and Zulu prince.

Buthelezi or Butelezi may also refer to:

• Buthelezi (tribe), a Zulu-speaking tribe in South Africa, assimilated under Shaka during the Mfecane, the name survives as a surname

• Anna Buthelezi (born 1965), South African politician
• Sbuyiselwe Angela Buthelezi (born 1969), South African politician
• Gideon Buthelezi (born 1986), South African light flyweight boxer
• Linda Buthelezi (born 1969), South African footballer who played as a midfielder
• Mbongeni Buthelezi (born 1956), South African artist who "painted" in plastic
• Melusi Buthelezi (born 1998), South African soccer player
• Peter Fanyana John Butelezi, South African archbishop, Roman Catholic Archdiocese of Bloemfontein

This disambiguation page lists articles associated with the title Buthelezi.
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