Apple of Sodom (Calotropis procera) is a species of milkweed in the family Apocynaceae native to the Dead Sea and Sodom, Israel and other desert regions.

Apple of Sodom may also refer to:

• Solanum carolinense or Carolina horsenettle, a nightshade native to North America
• Solanum linnaeanum or devil's apple, formerly Solanum sodomeum, an invasive nightshade native to South Africa
• Solanum mammosum or nipplefruit, a nightshade native to South America
• "Apple of Sodom" (song), a song by Marilyn Manson
• Apples of Sodom, a 1913 Edison film

• Soda apple

This disambiguation page lists articles associated with the title Apple of Sodom.
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