Apalachicola may refer to:

• Apalachicola band, an association of Native American towns along the Apalachicola River in Florida in the early 19th century
• Apalachicola Province, an association of Native American towns on the Chattahoochee River in Alabama and Georgia that became the Lower Towns of the Muscogee Confederacy
• Apalachicola (tribal town), a Native American town that was the namesake of the Apalachicola Province

• Apalachicola, Florida
• Apalachicola River
• Apalachicola Bay
• Apalachicola National Forest
• Apalachicola Regional Airport
• Port of Apalachicola

• Apalachicola and Alabama Railroad
• Apalachicola Northern Railroad

• Apalachicola (YTB-767), a tugboat in the United States Navy.

This disambiguation page lists articles associated with the title Apalachicola.
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