Ang Tanging Ina Mo (Last na 'To!) (lit. '"Your Only Mother (The Last One!)")' is a 2010 Filipino comedy drama film starring Ai-Ai delas Alas, Eugene Domingo, and certain others. An official entry for the 2010 Metro Manila Film Festival, it was supposed to be the last film of Ang Tanging Ina film series; however, a crossover sequel between Enteng Kabisote and Ang Tanging Ina entitled Enteng Ng Ina Mo co-starring Ai-Ai de las Alas and Vic Sotto were released. It was a co-production between APT Entertainment, M-ZET Productions, OctoArts Films and Star Cinema.

The crossover sequel was indirectly confirmed by Kris Aquino in her talk show Kris TV after discussing some of the entries of 2011 Metro Manila Film Festival including her film entry Segunda Mano which was also distributed by Star Cinema.

A few months after Ina resigns as President of the Philippines, she is back in the media limelight after releasing her memoir while living a simple life with her beloved children, together with her long-time best friend, Rowena.

After collapsing at President Ren's wedding, Ina undergoes an X-ray and medical examination. Her doctor tells her that she has brain tumor and only has 6 to 8 months to live. Ina has a hard time telling her children that about this. She is also has visions of her departed husbands, who turn out to be lookalikes of them. As her condition continues, Ina also deals with Seven's impending wedding with William, whom she dislikes, and infighting between her children. She thinks Juan, her first son, is in New Zealand but actually lives on the streets and accumulating debt. Pip turns out to have a daughter named Monay. Tudis quarrels with her husband, Troy, because of her daughter being with another man. When Ina's children find out about her sickness, they are heartbroken and decide to change for the better, especially Juan and Tri. After collapsing again at an event, Ina is rushed to the hospital, where Rowena is also due to give birth. All the children except Por arrive at her bedside. Ina initially thinks a light outside the room is God, which turns out to be from a film shoot. Then, another doctor arrives and says Ina has recovered. Ina and her family then celebrate the christening of Rowena's daughter when Frank, whom Ina has a crush on, arrives. Seven then gets married.

• Ai-Ai delas Alas as Ina Montecillo
• Eugene Domingo as Rowena
• Marvin Agustin as Juan Montecillo
• Nikki Valdez as Getrudis "Tudis" Montecillo
• Carlo Aquino as Dimitri "Tri" Montecillo
• Alwyn Uytingco as Tirso "Pip" Montecillo
• Marc Acueza as Sixto "Six" Montecillo
• Shaina Magdayao as Severina "Seven" Montecillo
• Serena Dalrymple as Catherine "Cate" Montecillo
• Jiro Manio as Samuel "Shammy" Montecillo
• Yuuki Kadooka as Martin "Ten-Ten" Montecillo
• Bianca Calma as Connie Montecillo
• Janella Calma as Sweet Montecillo
• Xyriel Manabat as Monay Montecillo
• Kaye Abad as Jenny Montecillo
• Jon Avila as Frank
• Rafael Rosell as Troy
• Debraliz as Doctor 2
• Ricky Rivero as Doctor 1
• Cecil Paz as Malena
• DJ Durano as Harold
• Bea Saw as one of the interview team
• Cherry Pie Picache as President Ren Constantino
• Tonton Gutierrez as Joe/Dr. Alfredo Monteagudo
• Jestoni Alarcon as Kevin/Francisco "Kiko" Montecillo
• Dennis Padilla as Nick/Eduardo "Eddie" Montenegro
• Empoy Marquez as William
• John Lapus as Dr. Mahatma Gandi

In 2011, there was a rumored crossover between Enteng Kabisote and Ang Tanging Ina titled Enteng ng Ina Mo. The film was an official entry for the 2011 Metro Manila Film Festival which was released on December 25, 2011. It breaks the four-day record of The Unkabogable Praybeyt Benjamin with a record of ₱110 million.

• The characters of Joe, Nick and Kevin were derived from the Jonas Brothers.
• In the wedding of President Ren Constantino, she was covered by a white cloth. This is similar to the wedding of Korina Sanchez to Mar Roxas where Sanchez was approaching the Church while covered with a white cloth.

• Ang Tanging Ina (film series)
• Ang Tanging Ina
• Enteng ng Ina Mo