ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5ME gene.^[3][4]

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ATP5ME
Identifiers
Aliases	ATP5ME, ATP5K, ATP synthase, H+ transporting, mitochondrial Fo complex subunit E, ATP synthase membrane subunit e, ATP5I
External IDs	OMIM: 601519; HomoloGene: 136813; GeneCards: ATP5ME; OMA:ATP5ME - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 672,436 bp[1] End 674,330 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right auricle mucosa of transverse colon tendon of biceps brachii C1 segment Brodmann area 9 internal globus pallidus right ventricle muscle of thigh n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity transmembrane transporter activity proton transmembrane transporter activity protein-containing complex binding Cellular component mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial proton-transporting ATP synthase complex mitochondrion membrane proton-transporting ATP synthase complex, coupling factor F(o) Biological process ATP metabolic process mitochondrial ATP synthesis coupled proton transport ATP synthesis coupled proton transport ion transport ATP biosynthetic process cristae formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 521 n/a Ensembl ENSG00000169020 n/a UniProt P56385 n/a RefSeq (mRNA) NM_007100 n/a RefSeq (protein) NP_009031 n/a Location (UCSC) Chr 4: 0.67 – 0.67 Mb n/a PubMed search [2] n/a
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Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex.^[4]

In yeast, the F_O complex E subunit appears to play an important role in supporting F-ATPase dimerisation. This subunit is anchored to the inner mitochondrial membrane via its N-terminal region, which is involved in stabilising subunits G and K of the F_O complex. The C-terminal region of subunit E is hydrophilic, protruding into the intermembrane space where it can also help stabilise the F-ATPase dimer complex.^[5]