AM-679_(FLAP_inhibitor)

AM-679 (FLAP inhibitor)

AM-679 (FLAP inhibitor)

Chemical compound

This article is about the FLAP inhibitor. For the cannabinoid agonist, see AM-679 (cannabinoid).

AM-679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM-679 has anti-inflammatory effects in animal studies.[1][2]

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References

  1. [1]
    Stock N, Baccei C, Bain G, Broadhead A, Chapman C, Darlington J, et al. (January 2010). "5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor". Bioorganic & Medicinal Chemistry Letters. 20 (1): 213–217. doi:10.1016/j.bmcl.2009.10.131. PMID 19914828.
  2. [2]
    Musiyenko A, Correa L, Stock N, Hutchinson JH, Lorrain DS, Bain G, et al. (November 2009). "A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye". Clinical and Vaccine Immunology. 16 (11): 1654–1659. doi:10.1128/CVI.00220-09. PMC 2772391. PMID 19759251.
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