4-hydroxybutyrate_dehydrogenase

4-Hydroxybutyrate dehydrogenase

4-Hydroxybutyrate dehydrogenase

Class of enzymes

In enzymology, a 4-hydroxybutyrate dehydrogenase (EC 1.1.1.61) is an enzyme that catalyzes the chemical reaction

4-hydroxybutanoate + NAD+ succinate semialdehyde + NADH + H+
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The two substrates of this enzyme are therefore 4-hydroxybutanoic acid, and NAD+, whereas its 3 products are succinate semialdehyde, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.[1] The systematic name of this enzyme class is 4-hydroxybutanoate:NAD+ oxidoreductase. This enzyme is also called gamma-hydroxybutyrate dehydrogenase. This enzyme participates in butanoate metabolism and the degradation of the neurotransmitter 4-hydroxybutanoic acid.[2]

References

  1. [1]
    Nirenberg MW, Jakoby WB (1960). "Enzymatic utilization of gamma-hydroxybutyric acid". J. Biol. Chem. 235: 954–960. PMID 14427301.
  2. [2]
    Kaufman EE, Nelson T (1991). "An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway". Neurochem. Res. 16 (9): 965–974. doi:10.1007/BF00965839. PMID 1784339.


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