3b-hydroxy-5b-steroid_dehydrogenase

3beta-hydroxy-5beta-steroid dehydrogenase

3beta-hydroxy-5beta-steroid dehydrogenase

Enzyme

In enzymology, a 3beta-hydroxy-5beta-steroid dehydrogenase (EC 1.1.1.277) is an enzyme that catalyzes the chemical reaction

3beta-hydroxy-5beta-pregnane-20-one + NADP+ 5beta-pregnan-3,20-dione + NADPH + H+
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Thus, the two substrates of this enzyme are 3beta-hydroxy-5beta-pregnane-20-one and NADP+, whereas its 3 products are 5beta-pregnan-3,20-dione, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3beta-hydroxy-5beta-steroid:NADP+ 3-oxidoreductase. Other names in common use include 3beta-hydroxysteroid 5beta-oxidoreductase, and 3beta-hydroxysteroid 5beta-progesterone oxidoreductase.

References

    • Stuhlemmer U, Kreis W (1996). "Cardenolide formation and activity of pregnane-modifying enzymes in cell suspension cultures, shoot cultures and leaves of Digitalis lanata". Plant Physiol. Biochem. 34: 85–91.
    • Seitz HU, Gaertner DE (1994). "Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea". Plant Cell. 38: 337–344. doi:10.1007/bf00033894.
    • Lindemann P, Luckner M (1997). "Biosynthesis of pregnane derivatives in somatic embryos of Digitalis lanata". Phytochemistry. 46 (3): 507–513. doi:10.1016/S0031-9422(97)00315-4.


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