3-dehydroquinate_synthase_II

3-dehydroquinate synthase II

3-dehydroquinate synthase II

Class of enzymes

3-dehydroquinate synthase II (EC 1.4.1.24, DHQ synthase II, MJ1249 (gene), aroB' (gene)) is an enzyme with systematic name 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating).[1] This enzyme catalyses the following chemical reaction

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ 3-dehydroquinate + NH3 + NADH + H+
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The enzyme was isolated from the archaeon Methanocaldococcus jannaschii.

References

  1. [1]
    White RH (June 2004). "L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii". Biochemistry. 43 (23): 7618–27. doi:10.1021/bi0495127. PMID 15182204.
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