3-(imidazol-5-yl)lactate_dehydrogenase

3-(imidazol-5-yl)lactate dehydrogenase

3-(imidazol-5-yl)lactate dehydrogenase

Class of enzymes

In enzymology, a 3-(imidazol-5-yl)lactate dehydrogenase (EC 1.1.1.111) is an enzyme that catalyzes the chemical reaction

(S)-3-(imidazol-5-yl)lactate + NAD(P)+ 3-(imidazol-5-yl)pyruvate + NAD(P)H + H+
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The 3 substrates of this enzyme are (S)-3-(imidazol-5-yl)lactate, NAD+, and NADP+, whereas its 4 products are 3-(imidazol-5-yl)pyruvate, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase. This enzyme is also called imidazol-5-yl lactate dehydrogenase.

References

    • Coote JG, Hassall H (January 1969). "The role of imidazol-5-yl-lactate-nicotinamide-adenine dinucleotide phosphate oxidoreductase and histidine-2-oxoglutarate aminotransferase in the degradation of imidazol-5-yl-lactate by Pseudomonas acidovorans". The Biochemical Journal. 111 (2): 237–9. PMC 1187811. PMID 4303364.
    • Cortese R, Brevet J, Hedegaard J, Roche J (1968). "[Identification and purification of an alpha-ketoacid aromatic reductase of Escherichia coli B]". Comptes Rendus des Séances de la Société de Biologie et de ses Filiales (in French). 162 (2): 390–5. PMID 4237631.


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