The 25-45 Sharps (6.35×45mm) is a firearms cartridge designed by Michael H Blank,^[2] then CEO of the Sharps Rifle Company, LLC, as a general hunting cartridge for most North American game, in particular deer, antelope, hogs, and coyotes.^[3] Unlike 300 AAC Blackout which was targeted specifically at the suppressed rifle market, and adapted to hunting, the 25-45 Sharps was designed primarily as a hunting round.

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That is not to say the round does not have tactical applications as its ballistics exceed that of the 5.56×45mm NATO cartridge. The cartridge name is derived from its caliber (.257 in (6.5 mm) bullet) and case length of 45 millimeters (necked-up 5.56×45 mm), as opposed to older hyphenated cartridges that were named for caliber and powder charge. Factory ballistics with the 87 gr (5.6 g) bullet equal those of the original .250-3000 Savage with the same bullet weight.

• 6×45mm
• 6.5×45 mm TCU
• 6 mm calibre
• Table of handgun and rifle cartridges