21-hydroxysteroid_dehydrogenase_(NADP+)

21-hydroxysteroid dehydrogenase (NADP<sup>+</sup>)

21-hydroxysteroid dehydrogenase (NADP+)

Enzyme

In enzymology, a 21-hydroxysteroid dehydrogenase (NADP+) (EC 1.1.1.151) is an enzyme that catalyzes the chemical reaction

pregnan-21-ol + NADP+ pregnan-21-al + NADPH + H+
Quick Facts +), Identifiers ...

Thus, the two substrates of this enzyme are pregnan-21-ol and NADP+, whereas its 3 products are pregnan-21-al, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NADP+ 21-oxidoreductase. Other names in common use include 21-hydroxy steroid dehydrogenase, 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), dehydrogenase, 21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide, phosphate), NADP+-21-hydroxysteroid dehydrogenase, and 21-hydroxysteroid dehydrogenase (NADP+).

References

    • Monder C, White A (1965). "The 21-hydroxysteroid dehydrogenases of liver. A nicotinamide adenine dinucleotide phosphate dehydrogenase and two nicotinamide adenine dinucleotide dehydrogenases". J. Biol. Chem. 240: 71–7. PMID 14253469.


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