The 2022 Big 12 Conference baseball tournament will be held from May 25 through 29 at Globe Life Field in Arlington, Texas. The annual tournament determines the conference champion of the Division I Big 12 Conference for college baseball. The winner of the tournament will earn the league's automatic bid to the 2022 NCAA Division I baseball tournament.^[2]

The tournament has been held since 1997, the inaugural year of the Big 12 Conference. Among current league members, Texas has won the most championships with five. Among original members, Kansas State has never won the event. Oklahoma State won their third championship in 2019. Iowa State discontinued their program after the 2001 season without having won a title. Having joined in 2013, TCU won titles in 2014, 2016, and 2021, while West Virginia has yet to win the Tournament.

The top eight finishers from the regular season will be seeded one through eight, and will then play a two-bracket double-elimination tournament leading to a winner-take-all championship game. At the beginning of the season, the conference coaches voted to make the higher seeded team the designated home team for all games in the tournament.