The 2021 NCAA Division I Men's Lacrosse Championship was the 50th annual single-elimination tournament to determine the national championship for National Collegiate Athletic Association (NCAA) Division I men's college lacrosse. Because the Ivy League did not participate in lacrosse this season, no play-in game was required.

Sixteen teams competed in the tournament based upon their performance during the regular season. For eight teams, entry into the tournament was by means of a conference tournament automatic qualifier and/or play in, while for the remaining eight teams at-large selection was determined by the NCAA selection committee.

Virginia took control over an undefeated Maryland team in the Championship Game, at one point leading 16–11. Maryland closed the gap in the fourth quarter scoring a goal with 10.8 seconds left to cut Virginia's lead to 17-16. Terps had an open shot on goal to tie the game with two seconds left off a Luke Weirman face off win, but a save by Alex Rode won the title for UVA. This was Virginia's seventh NCAA lacrosse title and second in the prior two NCAA tournaments (the 2020 NCAA tournament had been cancelled due to covid).

* Overtime

Tournament Finals (5/31/2021 at East Hartford, Conn. Pratt & Whitney Stadium)

Tournament Semi-Finals

Tournament Quarterfinals

Tournament First Round

Connor Shellenberger, Virginia (Most Outstanding Player)
Cade Saustad, Virginia
Alex Rode, Virginia
Petey LaSalla, Virginia
Jared Connors, Virginia
Matt Moore, Virginia
Nick Grill, Maryland
Logan Wisnauskas, Maryland
Jared Bernhardt, Maryland
William Perry, North Carolina

• For brackets, scores, seedings, All Tournament teams, refer to NCAA.com -- https://www.ncaa.com/history/lacrosse-men/d1
• For box scores, refer to individual university, college athletic web sites

• Virginia Wins Its Seventh NCAA National Title with 17-16 Win Over Maryland