The 2021 Big Ten Men's Lacrosse Tournament was held from May 1 to May 8. From this year, all six teams participate in the tournament while the top two teams in the regular season standings received first round byes. The first round matches were held on the campus of the higher seed teams, and the semifinals and final matches were held at the Panzer Stadium in University Park, Pennsylvania. The winner of the tournament received the Big Ten Conference's automatic bid to the 2021 NCAA Division I Men's Lacrosse Championship. The seeds were determined based on the teams' regular season conference record. Maryland won the tournament, beating Johns Hopkins 12–10.^[1]

Penn State earned seed #3 via a head-to-head tiebreaker over Ohio State. Michigan and Johns Hopkins were tied after applying all tiebreaking procedures. Michigan earned seed #5 by coin flip.^[2]

Not including Big Ten Tournament and NCAA tournament results

• MVP: Jared Bernhardt, Maryland
• All-Tournament Team
  • Garrett Degnon, Jr., M, Johns Hopkins
  • Matt Narewski, Jr., FO, Johns Hopkins
  • Jared Reinson, Sr., D, Johns Hopkins
  • Jared Bernhardt, Sr., A, Maryland
  • Anthony DeMaio, Sr., M, Maryland
  • John Geppert, Jr., LSM, Maryland
  • Nick Grill, Sr., D, Maryland
  • Brett Makar, Jr., D, Maryland
  • Josh Zawada, So., A, Michigan
  • Brennan Kamish, Sr., SSDM, Rutgers