2-oxoisovalerate_dehydrogenase_(acylating)

2-oxoisovalerate dehydrogenase (acylating)

2-oxoisovalerate dehydrogenase (acylating)

Class of enzymes

In enzymology, a 2-oxoisovalerate dehydrogenase (acylating) (EC 1.2.1.25) is an enzyme that catalyzes the chemical reaction

3-methyl-2-oxobutanoate + CoA + NAD+ 2-methylpropanoyl-CoA + CO2 + NADH
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The 3 substrates of this enzyme are 3-methyl-2-oxobutanoate, CoA, and NAD+, whereas its 3 products are 2-methylpropanoyl-CoA, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating). Other names in common use include 2-oxoisovalerate dehydrogenase, and alpha-ketoisovalerate dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation.

References

    • Namba Y, Yoshizawa K, Ejima A, Hayashi T, Kaneda T (1969). "Coenzyme A- and nicotinamide adenine dinucleotide-dependent branched chain alpha-keto acid dehydrogenase. I. Purification and properties of the enzyme from Bacillus subtilis". J. Biol. Chem. 244 (16): 4437–47. PMID 4308861.


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