In enzymology, a 2-dehydropantolactone reductase (A-specific) (EC 1.1.1.168) is an enzyme that catalyzes the chemical reaction

(R)-pantolactone + NADP⁺ ${\displaystyle \rightleftharpoons }$ 2-dehydropantolactone + NADPH + H⁺

Thus, the two substrates of this enzyme are (R)-pantolactone and NADP⁺, whereas its 3 products are 2-dehydropantolactone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantolactone:NADP⁺ oxidoreductase (A-specific). Other names in common use include 2-oxopantoyl lactone reductase, ketopantoyl lactone reductase, 2-ketopantoyl lactone reductase, and 2-dehydropantoyl-lactone reductase (A-specific).