2,5-dioxovalerate_dehydrogenase

2,5-dioxovalerate dehydrogenase

2,5-dioxovalerate dehydrogenase

Class of enzymes

In enzymology, a 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) is an enzyme that catalyzes the chemical reaction

2,5-dioxopentanoate + NADP+ + H2O 2-oxoglutarate + NADPH + 2 H+
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The 3 substrates of this enzyme are 2,5-dioxopentanoate, NADP+, and H2O, whereas its 3 products are 2-oxoglutarate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,5-dioxopentanoate:NADP+ 5-oxidoreductase. Other names in common use include 2-oxoglutarate semialdehyde dehydrogenase, and alpha-ketoglutaric semialdehyde dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.

References

    • Adams E, Rosso G (April 1967). "Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes". The Journal of Biological Chemistry. 242 (8): 1802–14. PMID 6024771.


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