A 1-up, or extra life, is a video game item.

1-UP, 1UP, 1Up, or one-up may also refer to:

• 1Up.com, a defunct video game website
• 1UP!, a 2009 album by illScarlett
• 1UP (T-Pain album), a 2019 album by T-Pain
• 1-Up Studio, a Japanese video game studio formerly known as Brownie Brown
• One-upmanship, successively outdoing a competitor
• 1Up (film), a movie from 2022
• "One Up", a song by Central Cee

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