16a-hydroxysteroid_dehydrogenase

16-alpha-hydroxysteroid dehydrogenase

16-alpha-hydroxysteroid dehydrogenase

Class of enzymes

In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction

a 16alpha-hydroxysteroid + NAD(P)+ a 16-oxosteroid + NAD(P)H + H+
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The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD+, and NADP+, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)+ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.

References

    • Meigs RA, Ryan KJ (1966). "16-alpha-hydroxysteroid dehydrogenase of rat kidney. Purification, assay, and properties". J. Biol. Chem. 241 (17): 4011–5. PMID 4380686.


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