In enzymology, a 15-hydroxyprostaglandin dehydrogenase (NADP⁺) (EC 1.1.1.197) is an enzyme that catalyzes the chemical reaction

(13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP⁺ ${\displaystyle \rightleftharpoons }$ (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH + H⁺

Thus, the two substrates of this enzyme are (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate and NADP⁺, whereas its 3 products are (13E)-11alpha-hydroxy-9,15-dioxoprost-13-enoate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP⁺ 15-oxidoreductase. Other names in common use include NADP⁺-dependent 15-hydroxyprostaglandin dehydrogenase, NADP⁺-linked 15-hydroxyprostaglandin dehydrogenase, NADP⁺-specific 15-hydroxyprostaglandin dehydrogenase, type II 15-hydroxyprostaglandin dehydrogenase, and 15-hydroxyprostaglandin dehydrogenase (NADP⁺).

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PFG.